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Title: Acetylcholinesterase Levels in Farmers Exposed to Pesticides in Malaysia.
Authors: Ishak, Ismarulyusda
Lubis, Syarif Husin
Hamid, Zariyantey Abd
Mohammad, Nihayah
Othman, Hidayatulfathi
Ghazali, Ahmad Rohi
Ismail, Muhammad Faiz Mohd
Sasitharan, Shobna
Keywords: Pesticides
Issue Date: Oct-2015
Citation: Ishak Ismarulyusda, Lubis Syarif Husin, Hamid Zariyantey Abd, Mohammad Nihayah, Othman Hidayatulfathi, Ghazali Ahmad Rohi, Ismail Muhammad Faiz Mohd, Sasitharan Shobna. Acetylcholinesterase Levels in Farmers Exposed to Pesticides in Malaysia. International Journal of Applied Biology and Pharmaceutical Technology. 2015 Oct-Dec; 6(4): 106-111.
Abstract: Agriculture is an important component of the Malaysian economy. Pesticides are widely used by farmers to increase crop production. Acetylcholinesterase (AChE) is known to play an important role in the degradation of acetylcholine (ACh) at the neuromuscular junction of the nervous system. The purpose of this study was to determine the effect of pesticide exposure on serum levels of AChE of farmers. A cross-sectional study was conducted. A total of 95 farmers from Kelantan (n = 49) and Selangor (n = 46) aged between 23 and 71 years were recruited. AChE concentration was measured by spectrophotometry. The results of this study showed that the mean AChE concentrations in farmers from Kelantan and Selangor were 2,715 and 2,660 U/L, respectively, significantly different (p < 0.05) from normal reference value (3500 U/l). Pearson correlation test showed a moderate correlation between AChE level and age (r = - 0.551) and a strong correlation between AChE level and working period (r = -0.872) in farmers in Kelantan. AChE levels in Selangor were also moderately correlated with age (r = -0.353) and working period (r = -0.515). In conclusion, increasing age and long-term pesticide exposure reduce AChE levels in farmers.
ISSN: 0976-4550
Appears in Collections:International Journal of Applied Biology and Pharmaceutical Technology

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