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Title: Anti-Helminthic Potential of Solvent Extracts of Indigenous Botanicals.
Authors: Jain, Rashmi
Ansari, Shabista
Aswal, Deepali
Mathur, Abhishek
Keywords: Anti-helminthic potential
hydro-alcoholic extracts
Azadirachta indica
Swertia chirayta
Issue Date: Oct-2015
Citation: Jain Rashmi, Shubham, Ansari Shabista, Aswal Deepali, Mathur Abhishek. Anti-Helminthic Potential of Solvent Extracts of Indigenous Botanicals. International Journal of Applied Biology and Pharmaceutical Technology. 2015 Oct-Dec; 6(4): 102-105.
Abstract: Ethno botanical studies reveal that the indigenous knowledge of a community is a key player in the identification of medicinal plants and such plants have been often tested by generations of indigenous people. In the present investigation, the hydro-alcoholic extracts of leaves of Azadirachta indica (Neem) and Swertia chirayta (Chirayta) were assessed for anti-helminthic potential against helminths (earthworms were used as model) at 10, 50 and 100 mg/ml. No anti-helminthic potential was observed at 10 mg/ml of dose of the hydro-alcoholic extracts of Swertia chirayta. The hydro-alcoholic extracts of both the plants showed significant anti-helminthic activity on selected worms at higher doses. Hydro-alcoholic leaves extracts of Azadirachta indica (Neem) was found to be more active as compared to hydro-alcoholic whole plant extracts of Swertia chirayta (Chirayta) at concentration of 100 mg/ml. It was observed that with the variation in dose, the death time and paralysis time of the worms’ decreases. The results indicated that extracts possessed dose dependent anti-helminthic activity. The results were compared to Piperazine citrate and Albendazole (15 mg/ml). The hydro-alcoholic extracts demonstrated paralysis as well as death of worms in a less time in comparison to the standard drugs. The anti-helminthic activity of the extracts indicates the presence of active principle responsible for anti-helminthic activity.
ISSN: 0976-4550
Appears in Collections:International Journal of Applied Biology and Pharmaceutical Technology

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