Please use this identifier to cite or link to this item: http://imsear.hellis.org/handle/123456789/169099
Title: The Impact of Iron Deficiency on HBA2 Level in Beta Thalassemia Minor in Sulaimani Northeastern Iraq.
Authors: Kamal, Awaz Ahmed
Jalal, Sana Dlawar
Mohammed, Dler Jaza
Keywords: HbA2
thalassemia minor
iron deficiency
anemia
Issue Date: Oct-2015
Citation: Kamal Awaz Ahmed, Jalal Sana Dlawar, Mohammed Dler Jaza. The Impact of Iron Deficiency on HBA2 Level in Beta Thalassemia Minor in Sulaimani Northeastern Iraq. International Journal of Applied Biology and Pharmaceutical Technology. 2015 Oct-Dec; 6(4): 59-62.
Abstract: Background: HbA2 plays a key role in screening programs for beta thalassemia because a small increase in this fraction is the most important marker of beta thalassemia heterozygous carriers. The potential impact of coincident iron deficiency on HbA2 based identification of beta thalassemia minor is worrisome issue for screening laboratories, this is especially true for resource-constrained settings where iron deficiency is wide spread and molecular confirmatory tests for borderline HbA2 values may be unavailable. Objective: the aim of this study is to evaluate the effect of iron deficiency on HbA2 level in order to improve the detection of beta thalassemia trait with or without iron deficiency in our population. Materials and Method: In this study 145 individuals were enrolled including normal controls (50), beta thalassemia minor (50) and coincident beta thalassemia with iron deficiency cases (45). Complete blood count, serum iron, total iron binding capacity and HbA2 with HbF estimation were done for every individual. Result: The mean HbA2 level was (2.4± 0.4) in control, (5.2 ± 0.9) in beta thalassemia minor and 5.1± 0.9 in coincident iron deficiency with beta thalassemia minors. All hematological parameters were significantly lower in beta thalassemia minor and coincident iron deficiency with beta thalassemia minor in comparison to the control group .Mean HbA2 level did not show a significant difference in thalassemia minor (5.2±0.9) when compared with the mean HbA2 levels in coincident iron deficiency with beta thalassemia minor. Conclusion: The presence of iron deficiency did not preclude the detection of beta thalassemia minor in our population.
URI: http://imsear.hellis.org/handle/123456789/169099
ISSN: 0976-4550
Appears in Collections:International Journal of Applied Biology and Pharmaceutical Technology

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