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Title: Immunomodulatory activity of methanolic leaf extract of moringa oleifera in animals.
Authors: Sudha, P
Asdaq, Syed Mohammed Basheeruddin
Dhamingi, Sunil S
Chandrakala, Gowda Kallenahalli
Keywords: cellular immunity
humoral immunity
Moringa oleifera
Issue Date: Apr-2010
Citation: Sudha P, Asdaq Syed Mohammed Basheeruddin, Dhamingi Sunil S, Chandrakala Gowda Kallenahalli. Immunomodulatory activity of methanolic leaf extract of moringa oleifera in animals. Indian Journal of Physiology and Pharmacology. 2010 Apr-June; 54(2): 133-140.
Abstract: Aim: The aim of the present study was to investigate the immunomodulatory action of methanolic extract of Moringa oleifera (MEMO) in an experimental model of immunity. The cellular immunity was evaluated using neutrophil adhesion test, cyclophosphamide induced neutropenia and carbon clearance assay, whereas, humoral immunity was tested by mice lethality test, serum immunoglobulin estimation and indirect haemagglutination assay in animals. Administration of MEMO (250 and 750 mg/kg, po) and Ocimum sanctum (100 mg/kg, po) significantly increased the levels of serum immunoglobulins and also prevented the mortality induced by bovine Pasteurella multocida in mice. They also increased significantly the circulating antibody titre in indirect haemagglunation test. Moreover, MEMO produced significant increase in adhesion of neutrophils, attenuation of cyclophosphamideinduced neutropenia and an increase in phagocytic index in carbon clearance assay. From the above results, it can be concluded that MEMO stimulate both cellular and humoral immune response. However, low dose of MEMO was found to be more effective than the high dose.
Appears in Collections:Indian Journal of Physiology and Pharmacology

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