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Title: Anxiolytic effects of Equisetum arvense Linn. extracts in mice.
Authors: Singh, Navdeep
Kaur, Sarabjit
Bedi, P M S
Kaur, Divneet
Keywords: Anti-anxiety
Equisetum arvense
Ethanol extract
Issue Date: May-2011
Citation: Singh Navdeep, Kaur Sarabjit, Bedi P M S, Kaur Divneet. Anxiolytic effects of Equisetum arvense Linn. extracts in mice. Indian Journal of Experimental Biology. 2011 May; 49(5): 352-356.
Abstract: The petroleum ether (PE), chloroform (CH), ethanol (ETH) and water extracts of E. arvense stems were evaluated for anti-anxiety activity in mice using elevated plus maze model. Ketamine induced hypnosis and actophotometer was used to evaluate sedative effect with various extracts in mice. The results were compared with standard drug diazepam. The ethanolic extract of E. arvense (50 and 100 mg/kg) significantly increased the time-spent and the percentage of the open arm entries in the elevated plus-maze model which was comparable to diazepam. Ethanolic extract (100 mg/kg) prolonged the ketamine-induced total sleeping time and decreased the locomotor activity in mice. The results suggest that the ethanolic extract of E. arvense seems to possess anxiolytic effect with lower sedative activity than that of diazepam. The results could be attributed to the flavonoid content of the ethanolic extract.
Appears in Collections:Indian Journal of Experimental Biology

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